Use Call-and-Response in Your Blues Leads
One of the fundamental concepts of blues soloing is something called call and response. Call and response can take all kinds of forms, two familiar ones being the way a guitarist or harp player answers a vocal line with an instrumental lick and the way a pianist or horn section answers a soloist with a riff-style response.
You can create call-and-response moments within your own soloing, too. In Example 7a, the lick in measure 1 is answered, after a suspenseful pause, by the descending lick in measure 3. Example 7b has the same kind of phrasing, with different licks plugged in.
Excerpted from Acoustic Guitar Lead and Melody Basics